Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.

Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.

heart disease remains the No. 1 killer in America; nearly half of all Americans have high blood pressure, high cholesterol, or smoke—some of the leading risk factors for heart disease…

—Murphy et al., 2018

Despite the high mortality rates associated with cardiovascular disorders, improved treatment options do exist that can help address those risk factors that afflict the majority of the population today.

As an advanced practice nurse, it is your responsibility to recommend appropriate treatment options for patients with cardiovascular disorders. To ensure the safety and effectiveness of drug therapy, advanced practice nurses must consider aspects that might influence pharmacokinetic and pharmacodynamic processes such as medical history, other drugs currently prescribed, and individual patient factors.

Reference: Murphy, S. L., Xu, J., Kochanek, K. D., & Arias, E. (2018). Mortality in the United States, 2017. Retrieved from https://www.cdc.gov/nchs/products/databriefs/db328.htm

To Prepare

• Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece.
• Review the case study assigned by your Instructor for this Assignment.
• Select one the following factors: genetics, gender, ethnicity, age, or behavior factors.
• Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes.
• Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy.
• Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.
• Write a 3-page paper that addresses the following:
  • Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.
  • Describe how changes in the processes might impact the patient’s recommended drug therapy. Be specific and provide examples.
  • Explain how you might improve the patient’s drug therapy plan and explain why you would make these recommended improvements.

Reminder: The College of Nursing requires that all papers submitted include a title page, introduction, summary, and references. The College of Nursing Writing Template with Instructions provided at the Walden Writing Center offers an example of those required elements (available at https://academicguides.waldenu.edu/writingcenter/templates/general#s-lg-box-20293632). All papers submitted must use this formatting.

week 2 Case for your Study!

• Please read the whole message.Patient JJ has a history of strokes. The patient has been diagnosed with type 2 diabetes, hypertension, and hyperlipidemia. Drugs currently prescribed include the following:

• 1. Glipizide 10 mg po daily
  2. Metformin 500 mg po daily
  3. HCTZ 25 mg daily
  4. Atenolol 25 mg po daily
  5. Hydralazine 25 mg qid
  6. Simvastatin 80 mg daily
  7. Verapamil 180 mg CD daily

Facilitator/Professor help:

• 1. Discuss pharmacology of existing agents briefly, molecular mechanism of action, therapeutic & adverse effects, & relevant kinetics, all as short paragraphs, readable.
• 2. Talk about what modifications are needed, what drugs are not at the best interest.
• 3. Follow a guideline, preferably JNC 8 and its current modifications (also ACC/AHA 2019 guidelines).
• 4. Talk about the drugs you have substituted or added, & their key pharmacology.
• 5. Address any specific questions that you are asked for in this case.Example, here are some questions you may want to address in your assignment: Does this patient need both verapamil & atenolol at the same time, since both have similar actions?
• Recent guidelines do not recommend beta blockers for hypertension. But it was possibly added for the best therapeutic outcome?
  Why beta blockers? (example, he had strokes?). Is there a drug to be added for stroke prevention?What are the major adverse effects of Statins (muscle related), Hydralazine (many, lupus like syndrome), glipizide (hypoglycemia) HCTZ (hypokalemia) etc.Why can’t this patient be a candidate for metformin, the best used diabetes drug, efficacious, no hypoglycemic attacks etc.?

Requirements: 3 page

Subject: Masters Nursing

here is a copy of the book..

https://drive.google.com/file/d/19QZ19iMAX6CkhqR2OYcfcaZ2yoqm2NlY/view?usp=drivesdk

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